What Is VDR?

VDR is a gene which encodes a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene known as the business direction rs2228570 (FokI polymorphism), is associated with reduced bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern as well as the temporal occupancy of the VDRE between the two components. It is also modulated by chromosomal location and binding preferences for specific hormones. Studies of microarrays in human cells show that over 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online storage facility for data and documents that are relevant to business, legal transactions or other proceedings that have restrictions on viewing printing, downloading, or viewing. It uses a central computer as well as an extranet that is a restricted-access Internet connection, allowing users to login at specified times.

Investment bankers and companies involved in mergers and acquisitions are among the most frequent users of VDRs. VDR. They need to be able to share information in a transparent manner with potential investors or buyers. Due diligence procedures can also require a large amount of information. Life science companies also utilize VDRs to store everything from clinical trial results to HIPAA documentation.