How a Vitamin D Receptor Functions
Posted by: sostohegy_admin | Posted on: October 25, 2023VDRs are used in a variety of ways however the most popular is used for M&A procedures. These procedures require that an extensive amount of documents be analyzed and exchanged between the parties. Utilizing VDRs VDR can ensure the secure, reliable and quick transfer of these documents.
Members may consider introducing a central analysis of their VDR downloads in order to identify patterns that could potentially lead to incidents on board. This could also allow Members to take corrective and prevention actions prior to incidents actually happening.
The vitamin D receptor (VDR) is a transcription factor that regulates the expression/transcription of genes (genomic pathways) and the regulation of enzymes (non-genomic pathways). The VDR is located primarily in the nucleus. It binds ligand, typically 1,25-dihydroxyvitamin D3, to specific DNA sequences in the promoter region of target genes and activates or inhibits transcription.
For transcriptional activation, VDR requires a large multiprotein complex, dubbed the mediator complex (DRIP). It is comprised of a variety of domains which are linked to the zinc-finger DNA-binding region of the thyroid hormone receptors as well as the 9aaTAD (LXXLL) consensus core sequence, which is found in a variety of transcription factors. The most prominent component of the mediator complex is a protein known as Med220 that interacts with VDR/RXR heterodimers activated by ligands through one or more LXXLL motif.
A T > C alteration in the FokI polymorphism of the VDR removes exon 2’s translation start site which results in an RNA protein that is smaller and has a reduced ability to bind to DNA. It also hinders transcriptional activation. This variant has been linked with alterations in calcium absorption, BMD, and gene expression [5454.